Research Article

Geranylgeraniol (GGOH) as a Mevalonate Pathway Activator in the Rescue of Bone Cells Treated with Zoledronic Acid: An In Vitro Study

Figure 4

Western blot with anti-Rap1A/B antibody in bone cells (OBs and OCs). Effect of ZA (0.1, 25, and 100 μM) and GGOH (10, 20, 40, and 80 μM) on protein prenylation of (a) human osteoblasts and (b) human osteoclasts after 7 days. GAPDH was used as loading control for western. The results are expressed as fold change of p-Rap1A/B (prenylated Rap1A/B). The results are presented as the mean and standard deviation (). ANOVA tests and Bonferroni corrections for multiple comparisons were applied. Significant difference between controls and test groups: , .
(a)
(b)
(c)
(d)