The Different Effects of IFN-β and IFN-γ on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells

Figure 2

Comparison of antitumor activity of IFN-β-primed AFMSCs and IFN-γ-primed AFMSCs in vivo. (a) H460 cells with or without AFMSCs and IFN-β-primed, IFN-γ-primed, or IFN-β+IFN-γ-primed AFMSCs were injected into BALB/c mice subcutaneously. Tumor progression was monitored for 20 days, and tumor growth was expressed as the mean nodule size at various time points after tumor appearance. (b, c) H460 cells with or without (b) or (c) AFMSCs and IFN-β-primed, IFN-γ-primed, or IFN-β+IFN-γ-primed AFMSCs were injected into NOD/SCID mice subcutaneously. At 30 days after tumor inoculation, tumors were excised and weighed. In addition, another group of mice that received IFN-γ-primed AFMSCs were orally administered 1-MT at a dose of 1 mg/ml in drinking water before one day of injection. All values represent . Experiments were repeated 2 to 3 times. ns: not significant (, , and , or 5).

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