Research Article

Atypical Mesenchymal Stromal Cell Responses to Topographic Modifications of Titanium Biomaterials Indicate Cytoskeletal- and Genetic Plasticity-Based Heterogeneity of Cells

Table 2

List of genetic markers and cumulative fold values of expression from three donors. Italicized values indicate the highest level of cumulative fold values of expression.

Gene symbolGM PGM SLAGM modSLAOM POM SLAOM modSLACategory

ACTB10.782.900.8626.4772.732.77Control
RAF12.411.7721.72159.4017.4739.55Control
CTNNB15.433.7783.4467.3133.1641.68Control
GAPD2.432.986.701.406.34174.07Control
18S end control3.003.003.003.003.003.00Control
Nanog6.812.6221.924.2915.563.91Expression in undifferentiated cells/Maintenence of pluripotency
POU5F16.616.42259.53235.3848.558.81Expression in undifferentiated cells/Maintenence of pluripotency
DNMT3B5.094.24116.4426.1123.5138.12Expression in undifferentiated cells/Maintenence of pluripotency
GABRB35.775.31189.67222.7410.99126.86Expression in undifferentiated cells/Maintenence of pluripotency
BRIX4.791.503.883.036.0151.52Correlation to stemness
CD97.859.52687.1870.2131.6559.77Correlation to stemness
COMMD33.953.8997.32140.2132.07103.13Correlation to stemness
CRABP27.797.4742.1440.707.2558.92Correlation to stemness
FGF58.464.3036.9012.8521.9411.80Correlation to stemness
GRB73.692.334.4221.3110.231.96Correlation to stemness
IFITM111.0317.96485.025.0414.71100.14Correlation to stemness
IFITM21.500.943.272.711.861.54Correlation to stemness
IL6ST5.484.24170.5646.8719.4720.64Correlation to stemness
IMP21.881.683.534.416.9346.71Correlation to stemness
KIT12.844.703.5036.205.626.39Correlation to stemness
LIFR2.510.0018.35401.8597.8436.63Correlation to stemness
NOG0.870.4210.0619.353.534.46Correlation to stemness
NR6A11.041.364.343.596.101.09Correlation to stemness
PODXL3.772.4191.9122.157.089.14Correlation to stemness
REST3.112.720.463.982.92110.34Correlation to stemness
SEMA3A2.752.1738.4133.002.550.30Correlation to stemness
ACTC0.320.060.211.320.160.31Differentiation
CGB4.151.6810.7225.195.7515.10Differentiation
COL1A15.824.23112.6816.4712.3410.92Differentiation
DES5.586.733.4924.3142.5025.70Differentiation
FLT123.277.963.371.284.035.75Differentiation
FN12.362.2927.3728.449.0422.22Differentiation
GATA63.402.6310.145.282.284.11Differentiation
GFAP1.962.201.330.390.330.00Differentiation
LAMA11.971.0332.05133.1420.2672.38Differentiation
LAMB13.963.1128.62230.2235.29233.72Differentiation
LAMC13.452.2831.0443.539.3217.86Differentiation
NES3.001.4514.8224.333.676.19Differentiation
PECAM118.2219.321133.63824.7381.74411.08Differentiation
RUNX22.402.252.245.7413.2156.92Differentiation
SERPINA120.1720.9267.1711.0122.725.60Differentiation
SST0.080.987.811.820.000.00Differentiation
SYP7.303.5267.06182.4119.593.10Differentiation