Mechanical Stress Modulates the RANKL/OPG System of Periodontal Ligament Stem Cells via <i>α</i>7 nAChR in Human Deciduous Teeth: An In Vitro Study

<div>Effects of mechanical pressure on the osteogenic and the osteoclastic differentiation in PDLSCs. (a–c) qRT-PCR was performed to assess <i>RUNX2</i>, <i>ALP</i>, <i>RANKL</i>, and <i>OPG</i> expression levels in different groups. 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(d) The expression levels of RUNX2, ALP, RANKL, and OPG in PDLSCs from each group were examined via Western blot assays. The cyclic hydraulic pressure was performed with a fixed frequency of 0.1 Hz at different ranges for 2 hours/day for three consecutive days.</div>

Stem Cells International

fig2

Figure 2

Figure 2: Mechanical Stress Modulates the RANKL/OPG System of Periodontal Ligament Stem Cells via <i>α</i>7 nAChR in Human Deciduous Teeth: An In Vitro Study 

Figure 2 | Mechanical Stress Modulates the RANKL/OPG System of Periodontal Ligament Stem Cells via α7 nAChR in Human Deciduous Teeth: An In Vitro Study 