Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells

Figure 3

Signaling pathways involved in ICA-mediated BMSC proliferation, osteogenesis, angiogenesis, and migration. ICA promotes proliferation of BMSCs through signaling pathways such as MAPK, ERK, p38, Wnt/β-catenin, RhoA-TAZ, and ERα-Wnt/β-catenin. ICA promotes BMSC osteogenesis via signaling pathways such as RhoA-TAZ, JNK, Wnt/β-catenin, ERα-Wnt/β-catenin, and PI3K/Akt/eNOS/NO/cGMP/PKG. ICA promotes BMSC angiogenesis via PI3K/Akt/eNOS, EGF-EGFR, PI3K, and ERK1/2 signaling pathways. ICA promotes migration of BMSCs through the MAPK signaling pathway.