Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis

Figure 4

Effect of HLSC injection on liver function of MCDD-fed mice. Aspartate aminotransferase (AST) (a), alanine aminotransferase (ALT) (b) expressed as U/l, and albumin (c) expressed as g/dl were measured as biomarkers of liver cell injury in serum of control SCID mice (CTRL), in mice fed with MCDD for 4 weeks and injected with vehicle alone (NASH), and in MCDD-fed mice treated with intravenous injection of HLSCs at week 1 (Group 1, ), 2 (Group 2, ), or 3 (Group 3, ) and sacrificed at week 4. Data are expressed as deviation (SD). ANOVA with Newman-Keuls multicomparison test was performed; HLSC-treated mice versus NASH mice.

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