Stem Cells International / 2019 / Article / Fig 1

Research Article

Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells

Figure 1

M1 stimulates mitochondrial fusion in human iPSCs (iPSC-Foreskin-2 cell line) without inducing mesendodermal differentiation. (a) Mitochondrial morphology of human iPSCs, indicated by HSP60 staining. (b) Percentage of OCT3/4+ cells with different mitochondrial morphologies (). (c) Number of mitochondrial genomes per nuclear genome (). (d–g) mRNA expression of mitochondrial fission and fusion markers (d), cell proliferation markers (e), mesodermal cardiac transcription factors (f) ,and pluripotency markers (g) in human iPSCs treated with either DMSO vehicle control (control) or M1 at 5 or 10 μM for 48 hours (). Data are expressed as . , vs. control by one-way paired ANOVA with Dunnett’s post hoc test.

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