Metastable Reprogramming State of Single Transcription Factor-Derived Induced Hepatocyte-Like Cells

Figure 4

Graphical abstract describing the metastable hepatic state driven by Hnf1a. In contrast to the stable hepatic state driven by multiple hepatic factors (4a3 and GHF), the Hnf1a-mediated hepatic state is metastable and requires the continuous supply of either exogenous Hnf1a or small molecules.