Mesenchymal Stem Cells Alleviate Moderate-to-Severe Psoriasis by Reducing the Production of Type I Interferon (IFN-I) by Plasmacytoid Dendritic Cells (pDCs)
MSC infusions inhibited the inflammatory response in psoriatic mice. (a) Relative gene expression of proinflammatory cytokines (IL-17, IL-23, IL-1β, and IL-6), anti-inflammatory cytokine (IL-10), and keratinocyte differentiation makers (S100A7, S100A8, and S100A9) in the mouse back skin after MSC infusion. (b) The cytokine protein levels were evaluated by ELISA after MSC infusion in mouse serum. Data was represented as .#,##, and ### (control group vs. the untreated group in all cases); ,, and (untreated group vs. MSC-treated group). ND: no detectable.