MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing

<div>MSCs skew macrophages to M2 via transferring exosome-derived miR-223. (a) qRT-PCR analysis of miR-223 in macrophages cocultured with BMMSCs, BMMSC-ex, and BM/siRab27a. (b) Analysis of miR-223 in BMMSCs transfected with miR-223 mimics and inhibitors. (c) Analysis of miR-223 in exosomes derived from BMMSCs transfected with miR-223 mimics and inhibitors. (d) CD206-positive macrophages were assessed after being cocultured with exosomes derived from BMMSCs, which were transfected with miR-223 mimics or inhibitors (<span class="nowrap"><svg height="8.55521pt" id="M55" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 27.8368 8.55521" width="27.8368pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 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Stem Cells International

fig6

Figure 6

Figure 6: MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing 