Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro

<div>Changes in the expression of inflammatory and apoptosis-associated proteins. (a) The expression levels of inflammation-related proteins (TNF-<i>α</i>, IL-6, and NF-<i>κ</i>B) were significantly increased in the AKI+PBS group compared with the normal group and decreased in the AKI+USCs group compared with the AKI+PBS group. (A) Protein bands and statistical figures. (B) TNF-<i>α</i>. (C) IL-6. (D) NF-<i>κ</i>B. (b) The expression levels of apoptosis-related proteins (BAX and cleaved caspase-3) were significantly decreased in the AKI+USCs group compared with the AKI+PBS group, while the level of the antiapoptosis protein BCL-2 showed the reverse trend. (A) Protein bands and statistical figures. (B) BCL-2. (C) BAX. 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Stem Cells International

fig6

Figure 6

Figure 6: Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro 