Review Article

Human Amnion Epithelial Cell Therapy for Chronic Liver Disease

Figure 3

Differential expression of Ly6C distinguishes MDMs with opposing functions in tissue repair. During liver repair, monocytes recruited by the CCL2/CCR2 axis differentiate into profibrotic Ly6Chi-expressing MDMs. In contrast, monocytes recruited by the CX3CL1/CX3CR1 axis give rise to Ly6Clow MDMs. This subpopulation promotes the resolution of tissue repair and regression of fibrosis. CX3CL1 can induce a phenotypic switch of Ly6Chi MDMs to a Ly6Clow phenotype.