Mesenchymal Stromal Cells Are More Effective Than Their Extracellular Vesicles at Reducing Lung Injury Regardless of Acute Respiratory Distress Syndrome Etiology

Figure 4

Lung mechanics. Static lung elastance () and resistive () and viscoelastic () pressures in animals with experimental pulmonary ARDS (ARDSp) (a) and extrapulmonary ARDS (ARDSexp) (b). ARDS was induced by administration of Escherichia coli lipopolysaccharide intratracheally (ARDSp) or intraperitoneally (ARDSexp). Control mice (C) received saline solution intratracheally (Cp) or intraperitoneally (Cexp). After 24 h, ARDSp and ARDSexp animals were further randomized to receive saline (50 μL, SAL), bone marrow-derived MSCs (10⁵, 50 μL), or EVs (10⁵, 50 μL), stimulated (MSC serum, EV serum) or not (MSCs, EVs) with serum obtained from ARDSp or ARDSexp animals. Values were expressed as deviation of 6 animals per group. Significantly different from the corresponding C group (). Significantly different from the corresponding ARDS group ().

(a)

(b)