Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy

Table 3

Literature summary of AMSC in the antifibrotic process.

Researcher	Fibrogenic signal pathway involved	Delivery method	Animal model	Heterogeneity	Antifibrotic effect
Song et al. [50]	TGF-β1/Smad2/3/7	Tail vein	Rat UUO	Syngeneic	Yes
Burgos-Silva et al. [89]	Not mentioned	i.p.	AKI and CKI mouse models	Syngeneic	Yes
Donizetti-Oliveira et al. [90]	TGF-β	i.p.	Mouse IRI	Syngeneic	Yes
Zou et al. [91]	PAI-1	Carotid artery	Unilateral RAS mouse model	Syngeneic	Yes
Iwai et al. [93]	Not mentioned	Renal artery	Rat DCD renal transplantation	Syngeneic	Yes
Eirin et al. [95]	Not mentioned	Renal artery	RAS pig model	Autologous	Yes
Quimby et al. [96]	Not mentioned	i.v.	Cat CKD model	Allogeneic	No
Katsuno et al. [98]	Not mentioned	Renal subcapsule	Folic acid-induced AKI rat model	Xenogeneic (from human)	Yes
Chung et al. [99]	Not mentioned	Tail vein	CsA-induced nephropathy rat model	Xenogeneic (from human)	No
Zhu et al. [100]	TGF-β1/Smad3	Tail vein	Mouse IRI	Xenogeneic (from human)	Yes