Research Article

Notch Inhibition Promotes Differentiation of Liver Progenitor Cells into Hepatocytes via sox9b Repression in Zebrafish

Figure 4

LY411575 treatment rescues a defect in LPC-to-hepatocyte differentiation in MS-275-treated regenerating larvae. (a) Experimental scheme illustrating the periods of MTZ and compound treatment and analysis stage (arrow). (b) Single-optical section images showing fabp10a:CFP-NTR, Tp1:H2B-mCherry, and Bhmt expression in regenerating livers at R24h. (c) Quantification of the percentage of Bhmt+ hepatocytes among BEC-derived cells, as shown in (b). Scale bar: 100 μm; error bars: ±SEM. .
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