Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder

Figure 5

Enriched GO terms (in “cellular process” category) corresponding to 67 target genes associated with ASD. (a) Pie chart representing broad functional groups. The size of each category within a pie chart represents the percent of included terms. All enriched GO terms are statistically significant ( value < 0.01). Single and double asterisks indicate significant enriched GO terms at the group with value = 0.01 and the group with value < 0.01, respectively. (b) Networks of functional groups (shown in 5A) with matching color coding. Nodes with kappa , where only the label of the most significant term per functional group is shown. Color-filled large circles represent GO terms, and the circle size represents their enrichment significance. Tiny circles with red text label represent genes associated with one or multiple GO terms. All enriched GO terms shown in the network are statistically significant with a Benjamini-Hochberg corrected value of <0.01. These results are also shown in Table S2 under column “F.”

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