Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head

Figure 3

(a, 1) MRI T1-weighted (white arrow) suggests femoral head necrosis; (a, 2) X-ray guided minimally invasive decompression and implantation of MSC; (a, 3-4) MRI T1-weighted (12 months post-operation) shows femoral head edema decreased in the coronal plane (a, 3) and the axial plane (a, 4). (b, 1) Preoperative pelvic X-ray shows the necrosis zone; (b, 2) pelvic X-ray (60 months post-operation) shows the bone sclerosis band in the femoral head. (c) Harris Hip Score improvement with MSC therapy. (d) Concentrated MSC are of fibrogenic differentiation and osteogenic colony forming ability. (e) The proliferated MSC are of good differentiation potential of the three lineages. (f) The osteogenesis of MSC does not decline. Figure adapted from ref. [35].

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