Intra-Articular Injection of 2 Different Dosages of Autologous and Allogeneic Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells Triggers a Variable Inflammatory Response of the Fetlock Joint on 12 Sound Experimental Horses

Figure 5

Transverse ultrasound images of the lateral aspect (a-h) and dorsal aspect (i, j) of the fetlock joint of 4 horses taken on day 0 (D0) before MSC injections (a, c, e, g), on day 1 (D1) after injection (b, d, h, j), and on day 3 (D3) after injection (f, i) showing the different grades of synovial effusion measured on ultrasound. Note the aspect of the skin (arrow) from concave to convex and the amount of fluid () from mild to marked. (a, b) Right front fetlock of horse 1 injected with autologous BM-MSCs showing grade 0 synovial effusion on D0 (a) and grade 1 on D1 (b). (c, d) Left front fetlock of horse 10 injected with allogeneic UCB-MSCs showing grade 0 synovial effusion on D0 (c) and grade 2 on D1 (d). (e, f, i) Right front fetlock of horse 9 injected with allogeneic BM-MSCs showing grade 0 synovial effusion on D0 (e) and grade 3 on D3 (f, i). (g, h, j) Right front fetlock of horse 7 injected with autologous BM-MSCs showing grade 0 synovial effusion on D0 (g) and grade 4 on D1 (h, j).

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