Research Article

IL-1β Pretreatment Improves the Efficacy of Mesenchymal Stem Cells on Acute Liver Failure by Enhancing CXCR4 Expression

Figure 2

IL-1β pretreatment improved the protective effect of MSCs on the survival rate and liver function in ALF rats. (a) Flow chart of in vivo experiments. The rats were intraperitoneally administrated with CCL4 to induce ALF or with oil as control, followed by intravenous injection with NS, MSCs, or Pre-MSCs 6 h later. The observation group was observed for six days, and the specimens of rats in the other groups were collected at 24 h and 48 h after treatment. (b) The survival rate of rats dealt with different protocol was recorded every day (). (c) The levels of serum ALT (c), AST (d), TBIL (e), and ALB (f) were detected (). , #, and &.