Research Article
Safety and Localization of Mesenchymal Stromal Cells Derived from Human Adipose Tissue-Associated Hyaluronic Acid: A Preclinical Study
Table 1
Summary of the evaluation of the macroscopic alterations presented by the test systems after subcutaneous injection of the test substances.
| | Observation | Time | 30 min. | 24 hours | 48 hours | | Animals/group | Saline | HA 1% | ASC | ASC+HA1% | FAD | Saline | HA 1% | ASC | ASC+ HA1% | FAD | Saline | HA 1% | ASC | ASC+HA1% | FAD |
| | Bristly hair | 5 | 0% | 0% | 0% | 0% | 100% | 0% | 0% | 0% | 0% | 100% | 0% | 0% | 0% | 0% | 100% | | Discrete subcutaneous edema | 5 | 20% | 20% | 20% | 20% | 80% | 0% | 0% | 0% | 20% | 100% | 0% | 0% | 0% | 20% | 100% | | Subcutaneous increase in volume | 5 | 0% | 100% | 0% | 100% | 80% | 0% | 100% | 0% | 100% | 80% | 0% | 100% | 0% | 100% | 80% | | Subcutaneous petechiae | 5 | 0% | 0% | 20% | 20% | 80% | 0% | 0% | 0% | 0% | 60% | 0% | 0% | 0% | 0% | 0% | | Subacute inflammatory infiltrate in the deep dermis | 5 | 0% | 0% | 20% | 0% | 100% | 0% | 0% | 0% | 0% | 100% | 0% | 0% | 0% | 20% | 100% | | Discrete subacute dermatitis in the deep dermis | 5 | 0% | 0% | 0% | 20% | 100% | 0% | 0% | 0% | 20% | 80% | 0% | 0% | 0% | 20% | 80% | | Discrete subacute dermatitis in the superficial dermis | 5 | 0% | 0% | 0% | 0% | 100% | 0% | 0% | 0% | 0% | 80% | 0% | 0% | 0% | 0% | 20% | | Severe subacute dermatitis in the deep dermis | 5 | 0% | 0% | 0% | 0% | 20% | 0% | 0% | 0% | 0% | 20% | 0% | 0% | 0% | 0% | 20% | | Discrete chronic dermatitis in the deep dermis | 5 | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 20% | 0% | 80% | 0% | 0% | 0% | 0% | 0% | | Moderate chronic dermatitis in the deep dermis | 5 | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 20% | 0% | 80% | 0% | 0% | 0% | 0% | 0% |
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