The Efficacy of Mesenchymal Stem Cells in Therapy of Acute Kidney Injury Induced by Ischemia-Reperfusion in Animal Models

Table 2

Meta-analysis of the efficacy of MSC in therapy of acute kidney injury induced by ischemia-reperfusion.

Indicators	Timepoint	Study number	test value	Model selected	WMD (95% CI)
Scr	1 day	13	<0.00001	Random	-0.56 (-0.78, -0.34)	<0.00001
	2 days	5	0.0002	Random	-0.58 (-0.89, -0.28)	0.0002
	3 days	15	<0.00001	Random	-0.65 (-0.84, -0.45)	<0.00001
	5 days	4	<0.00001	Random	-0.35 (-0.54, -0.16)	0.0003
	7 days	7	<0.00001	Random	-0.14 (-0.28, -0.00)	0.05
	>7 days	5	<0.00001	Random	-0.22 (-0.36, -0.08)	0.002
BUN	1 day	7	0.04	Random	-11.72 (-18.80, -4.64)	0.001
	2 days	3	0.38	Fixed	-33.60 (-40.15, -27.05)	<0.00001
	3 days	10	<0.00001	Random	-21.14 (-26.15, -16.14)	<0.00001
	5 days	2	0.20	Fixed	-8.88 (-11.06, -6.69)	<0.00001
	7 days	2	0.79	Fixed	-0.72 (-13.49, -12.05)	0.91
	>7 days	2	<0.00001	Random	-90.84 (-257.31, 75.62)	0.28
Proteinuria	3 days	3	<0.00001	Random	-0.45 (-0.61, -0.30)	<0.00001
	>7 days	2	0.21	Fixed	-108.55 (-110.31, -106.78)	<0.00001
MDA	—	4	0.0001	Random	-5.51 (-10.57, -0.45)	0.03
GSH	—	2	0.0002	Random	-31.40 (-21.52, 84.31)	0.24
CAT	—	2	<0.00001	Random	10.82 (-4.30, 25.95)	0.16
SOD	—	2	0.41	Fixed	18.95 (16.86, 21.04)	<0.00001
NOX1	—	3	<0.00001	Random	-0.32 (-0.54, -0.10)	0.004
NOX2	—	4	<0.00001	Random	-0.19 (-0.28, -0.10)	<0.0001
PARP1	—	4	<0.00001	Random	-0.22 (-0.34, -0.09)	0.0006
Caspase 3 (mRNA)	—	2	<0.00001	Random	-3.40 (-6.13, -0.68)	0.01
Caspase 3 (protein)	—	3	<0.00001	Random	-0.15 (-0.21, -0.08)	<0.00001
Bax	—	3	<0.00001	Random	-0.25 (-4.42, -0.08)	0.004
TNF-α	—	5	<0.00001	Random	-0.15 (-0.31, -0.02)	0.08
NFκB	—	3	<0.00001	Random	-0.36 (-0.66, -0.05)	0.02
IL1β (mRNA)	—	2	0.007	Random	-3.26 (-4.37, -2.15)	<0.00001
IL1β (protein)	—	3	<0.00001	Random	-0.37 (-0.57, -0.17)	0.0003
IL4	—	2	<0.00001	Random	0.13 (0.02, 0.23)	0.02
IL6 (mRNA)	—	2	<0.00001	Random	-2.34 (-4.75, 0.07)	0.06
IL10 (mRNA)	—	2	0.13	Fixed	0.27 (0.24, 0.29)	<0.00001
IL10 (protein)	—	3	<0.00001	Random	0.45 (0.04, 0.86)	0.03
TGF-β	—	2	<0.00001	Random	-18.89 (-55.79, 18.02)	0.32
Renal damage score	1 day	4	<0.00001	Random	-14.50 (-19.10, -9.90)	<0.00001
	3 days	4	<0.00001	Random	-1.19 (-1.72, -0.66)	<0.0001

Note: Scr: serum creatinine; BUN: blood urea nitrogen; MDA: malondialdehyde; GSH: L-glutathione; SOD: superoxide dismutase; NOX1: NADPH oxidase-1; NOX2: NADPH oxidase-2; PARP1: poly(ADP-ribose) polymerase-1; TNF-α: tumor necrosis factor-α; Bax: Bcl-2 associated X protein; NFκB: nuclear factor kappa beta; IL1β: interleukin 1β; IL4: interleukin 4; IL6: interleukin 6; IL10: interleukin 10; TGF-β: transforming growth factor-β.