Stem Cells International / 2020 / Article / Fig 5

Research Article

Succinate Supplement Elicited “Pseudohypoxia” Condition to Promote Proliferation, Migration, and Osteogenesis of Periodontal Ligament Cells

Figure 5

Blocking HIF-1α affected genes that were involved in glycolysis and proliferation of hPDLCs during hypoxia incubation and succinate supplementation. hPDLCs were preconditioned with BAY 87-2243 to block HIF-1α for 3 h. Changes in metabolic and cell cycle-related genes at 4 h after hypoxia/succinate treatment were measured by qPCR () (a, b). , relative to control; , relative to control.

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