circRNA Expression Profile in Dental Pulp Stem Cells during Odontogenic Differentiation

Figure 4

GO and KEGG pathway analysis of noninduced and induced hDPSCs. GO analysis of 1345 upregulated differentially expressed mRNAs and 1058 differentially expressed downregulated mRNAs, respectively. (a) GO cellular component classification of upregulated mRNAs. (b) GO cellular component classification of downregulated mRNAs. (c) GO molecular function classification of upregulated mRNAs. (d) GO molecular function classification of downregulated mRNAs. (e) GO biological process classification of upregulated mRNAs. (f) GO biological process classification of downregulated mRNAs. KEGG pathway enrichment. The -axis represents the ratio of enriched differentiated genes to all genes enriched for a particular pathway term. Spot size represents the number of significantly differentiated genes; larger spots indicate more differentiated genes; the color of circle indicates the value including the signaling pathways regulating pluripotency of stem cells, the Wnt pathway, and the TGF-β pathway. (g) KEGG pathway analysis of upregulated mRNAs. (h) KEGG pathway analysis of downregulated mRNAs.

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