Clinical Efficacy and Safety of Stem Cell-Based Therapy in Treating Asherman Syndrome: A System Review and Meta-Analysis
Table 3
Checklist for quality assessment of the case series study.
Risk of bias
Criterion
Santamaria 2016
Singh 2014
Tan 2016
Cao. 2018
Singh 2020
Zhao 2016
Lee 2019
Ma 2020
Selection bias
Does the design or analysis control account for important confounding and modifying variables through matching, stratification, multivariable analysis, or other approaches?
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Performance bias
Did researchers rule out any impact from a concurrent intervention or an unintended exposure that might bias results?
Yes
Yes
NA
NA
NA
Yes
NA
Yes
Did the study maintain fidelity to the intervention protocol?
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Attrition bias
If attrition (overall or differential nonresponse, dropout, loss to follow-up, or exclusion of participants) was a concern, were missing data handled appropriately (e.g., intention to treat analysis and imputation)?
Yes
Yes
Yes
Yes
NA
Yes
NA
Yes
Detection bias
Were the outcome assessors blinded to the intervention or exposure status of participants?
NA
NA
NA
NA
NA
NA
NO
NA
Were interventions/exposures/assessed/defined using valid and reliable measures implemented consistently across all study participants?
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Were outcomes assessed/defined using valid and reliable measures implemented consistently across all study participants?
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Were confounding variable sassessed using valid and reliable measures implemented consistently across all study participants?
Yes
NA
NA
NA
NA
NA
NA
Yes
Reporting bias
Were the potential outcomes prespectified by the researchers? Are all prespecified outcomes reported?
