Review Article

Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence

Table 3

Known herbal active compounds with an antisenescence role on human senescent cells.

Compound nameStudied cellsTreatment doseTime exposureSenescence inducers (dose/time)Treatment (pre-, post-, and coinducer)Effects on cellsRef. number

MorinKSCs10-20-100 μM5-30-60 minutes or 24 hoursUVB exposure (30 mJ/cm2)Post-treatmentIncrease in cellular viability and decrease in senescence and DNA damage in UVB-treated cells; increase in the anti-inflammatory functions[231]

QuercetinBMSCs100 μM or 50 μM in long-term treatment1-3 days or long-term treatmentAbsent/No senolytic effects on replicative senescent MSCs[245]

QuercetinWS MSCs; HGPS MSCs; physiological-aging wild-type MSCs from a 56-year subject; replicative-senescent wild-type MSCs100 nmol/L7 days or 30 daysAbsent/Decrease in replicative senescence, oxidative stress, inflammation and apoptosis in WS MSCs; enhancement of osteogenic and chondrogenic differentiation in WS MSCs; attenuation of cellular senescence in HGPS MSCs and in both physiological-aging MSCs[244]

VanillinKSCs10-20-100 μM5-30-60 minutes or 24 hoursUVB exposure (30 mJ/cm2)Post-treatmentIncrease in cellular viability in UVB-treated cells; decrease in senescence, in DNA damage and in the production of inflammatory cytokines in UVB-treated cells[234]

ZingeroneKSCs10-20-100 μM60 minutes or 24 hoursUVB exposure (30 mJ/cm2)Post-treatmentEnhancement of cell viability; decrease in senescence and DNA damage; decrease in the production of inflammatory cytokines[237]

Herb compounds are shown in alphabetical order. BMSCs: bone marrow-derived mesenchymal stromal cells; HGPS: Hutchinson-Gilford progeria syndrome; MSCs: multipotent mesenchymal stromal cells; KSCs: keratinocyte stem cells; WS: Werner syndrome.