WS MSCs; HGPS MSCs; physiological-aging wild-type MSCs from a 56-year subject; replicative-senescent wild-type MSCs
100 nmol/L
7 days or 30 days
Absent
/
Decrease in replicative senescence, oxidative stress, inflammation and apoptosis in WS MSCs; enhancement of osteogenic and chondrogenic differentiation in WS MSCs; attenuation of cellular senescence in HGPS MSCs and in both physiological-aging MSCs
Increase in cellular viability in UVB-treated cells; decrease in senescence, in DNA damage and in the production of inflammatory cytokines in UVB-treated cells