The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review

Table 2

SUMOylation in different kinds of cancers.

Components	Expression	Effects on cancers
SUMO1, SUMO2/3	Upregulated	Silencing the expression of SUMO1 and SUMO 2/3 impairs cell growth and DNA synthesis in glioblastoma [141].; SUMO2/3 is critical for proliferation of Myc-driven lymphoma [123].
SAE1	Upregulated	SAE1 is positively related with lymph node metastasis of lung adenocarcinomas [121].; SAE1 is important for proliferation of Myc-driven lymphoma [123].; SAE1 promotes the progression of hepatocellular carcinoma [1].
SAE2	Upregulated	SAE2 can maintain the malignancy and reduce the chemotherapy sensitivity in SCLC [122].; SAE2 is critical for proliferation of Myc-driven lymphoma [123].
Ubc9	Upregulated	Negatively associated with survival rate of multiple myeloma [112].; Critical for proliferation of Myc-driven lymphoma [123].; Involves in human lung tumorigenesis [142].; Inversely correlated with the sensitivity of chemotherapy and prognosis of breast cancer [126].; Serves as an important molecule in melanoma-positive lymph nodes [128].
PIAS1	Upregulated	Negatively associated with survival rate of multiple myeloma [112].; Promotes breast tumorigenesis by selectively silencing the epigenetic genes [130].; Overexpressed PIAS1 is correlated with the development of colon cancer [143].
PIAS3	Upregulated	Increased expression of PIAS3 was observed in lung, breast, prostate, colon-rectum, and brain tumors [144].
PIAS4	Upregulated	Promotes the hypoxia-dependent EMT by regulating the transcriptional activity of SIRT1 [132].; Serves as an activator of hypoxia pathway in pancreatic cancer cells [133].
SENP1	Upregulated	Promotes the invasion of neuroblastoma by regulating the expression of MMP2, MMP9, and CDH1 [137].; Essential for the cell proliferation and migration of triple-negative breast cancer in vitro [145].; Increased level of SENP1 mRNA is correlated with cancer recurrence of bladder cancer [134].
SENP2	Downregulated	Limiting the expression of MMP13 and repressing the invasion and migration of bladder cancer [138].; Inhibiting the activation of NF-κB pathway and improving the sensitivity of breast cancer cells to doxorubicin [146].
SENP3	Upregulated	Associated with the differentiation of oral squamous cell carcinoma [139].; Regulating cell proliferation by the deSUMOylation of PML under oxidative stress in colon adenocarcinoma [147].; SENP3 regulates the activity of nuclear Nrf2 under reactive oxygen species stress induced by cisplatin in laryngeal carcinoma [148].
SENP5	Upregulated	Subcellular location of SENP5 is associated with differentiation of oral squamous cell carcinoma [149].; SENP5 promotes breast cancer invasion by mediating TGFβRI SUMOylation [140].