The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review

Table 3

The mechanism of SUMOylation inhibitors.

Targets	Small molecular inhibitors	Mechanism
E1-SUMO thioester complex	Ginkgolic acid	The structures of these small molecular inhibitors are similar, and all include a carboxylic acid, which is essential for the direct and specific binding with SUMO E1, and can interrupt the formation of E1-SUMO thioester complex to block the SUMOylation.
	Anacardic acid
	Kerriamycin B
Ubc9-SUMO thioester complex	Spectomycin B1	Spectomycin B1 can directly bind with Ubc9 and interrupt the formation of Ubc9-SUMO thioester complex.
Ubc9-targeted protein	2-D08	2-D08 can block the SUMOylation without affecting ubiquitin. 2-D08 mainly interrupts the transfer of SUMO1 from Ubc9 to the targeted proteins.