Research Article
Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney
Figure 7
MetS-EVs did not improve the renal mitochondrial function in MetS+RAS. (a) Mitochondrial hydrogen peroxide (H202) that increased in MetS compared to Lean and further increased in MetS+RAS, decreased in MetS+RAS+Lean-EVs, but not in MetS+RAS+MetS-EVs. (b) The cytochrome-c oxidase (COX)-IV activity and ATPADP ratio that decreased in MetS compared to Lean and further decreased in MetS+RAS, increased in MetS+RAS+Lean-EVs, but not in MetS+RAS+MetS-EVs. vs. Lean; † vs. MetS; ‡ vs. MetS+RAS; # vs. MetS+RAS+Lean-EVs.
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