Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance
KDM4C is required for the invasion and migration ability of ovarian cancer cells. (a, b) The knockdown of KDM4C by shRNA. KDM4C expression was examined by qRT-PCR and Western Blot analysis. Scramble shell (Scrsh) was used as the control. (c, d) Cell invasive ability of SK-OV-3 and HO-8910 cells determined by transwell assays was decreased after stable knockdown of KDM4C. (e, f) Migratory potential of SK-OV-3 and HO-8910 cells determined by wound-healing assays was decreased after stable knockdown of KDM4C. Scale bar, 100 μm. , .