Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance

<div>KDM4C is required for the invasion and migration ability of ovarian cancer cells. (a, b) The knockdown of KDM4C by shRNA. KDM4C expression was examined by qRT-PCR and Western Blot analysis. Scramble shell (Scrsh) was used as the control. (c, d) Cell invasive ability of SK-OV-3 and HO-8910 cells determined by transwell assays was decreased after stable knockdown of KDM4C. (e, f) Migratory potential of SK-OV-3 and HO-8910 cells determined by wound-healing assays was decreased after stable knockdown of KDM4C. 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Stem Cells International

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Figure 2

Figure 2: Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance 