Epigenetic Regulation of Dental Pulp Stem Cell Fate

Table 1

DNA methylation in DPSCs.

Epigenetic modifier	Epigenetic mark	Results
TET1	DNA demethylation	TET1, existing both in the cytoplasm and nuclei of the DPSCs, can improve the proliferation and odontogenic differentiation [102–104].
5-Aza-CdR	DNMT inhibitor	The inhibition of DNA methylation by 5-Aza negatively regulates the proliferation and enhances the myogenic and odontogenic differentiation [98, 100, 101].
RG108	DNMT inhibitor	SP1 can improve the expression of KLF4 through binding to the demethylated promoter region during the odontoblastic differentiation [99].