Epigenetic Regulation of Dental Pulp Stem Cell Fate
Table 1
DNA methylation in DPSCs.
Epigenetic modifier
Epigenetic mark
Results
TET1
DNA demethylation
TET1, existing both in the cytoplasm and nuclei of the DPSCs, can improve the proliferation and odontogenic differentiation [102ā104].
5-Aza-CdR
DNMT inhibitor
The inhibition of DNA methylation by 5-Aza negatively regulates the proliferation and enhances the myogenic and odontogenic differentiation [98, 100, 101].
RG108
DNMT inhibitor
SP1 can improve the expression of KLF4 through binding to the demethylated promoter region during the odontoblastic differentiation [99].