CHD7 Regulates Osteogenic Differentiation of Human Dental Follicle Cells via PTH1R Signaling

<div>RNA-seq revealed the downregulated enrichment of the PTH-related pathway after CHD7 depletion. (a) GO enrichment unraveled that skeletal system development and ossification were suppressed after <i>CHD7</i> depletion. (b) Heatmap of representative osteogenesis associated genes. (c) KEGG enrichment unraveled that the PTH-related pathway was significantly suppressed after <i>CHD7</i> depletion. (d) GSEA showed decreased enrichment of PTH-regulated genes in CHD7-deficient hDFCs.</div>

Stem Cells International

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Figure 4: CHD7 Regulates Osteogenic Differentiation of Human Dental Follicle Cells via PTH1R Signaling 