The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review

Table 1

Summary of included studies using BDSCs. Summary of isolation procedure and sampling, AGEs concentration, application duration, and effect on outcome measurement proliferation and apoptosis.

Study name	Year	Isolation SC/PC	AGEs application		Effect on outcome
			Concentration	Duration	Proliferation	Apoptosis
Bhatwadekar et al. [35]	2008	Human EPCs–peripheral blood, DGC	Fibronectin coated with 10, 50, & 100 μM MGO	24 hours	↘
Blackburn et al. [34]	2017	Human PBMC–peripheral blood, DGC	Collagen type I gel +1 mM MGO	4 days	↘
Chang et al. [36]	2017	Human EPCs–peripheral blood, DGC	500 μg/ml	24 hours	↘
Chen et al. [37]	2009	Human EPCs–umbilical cord blood, DGC	50, 100, 200, & 400 μg/ml	24 hours	-	↗
Chen et al. [44]	2019	Human EPCs–peripheral blood, DGC	200 μg/ml	48 hours	↘	↗
Li et al. [38]	2016	Human EPCs–peripheral blood, DGC	50, 100, & 200 μg/ml	24, 48, and 72 hours	↘
Liang et al. [39]	2009	Human EPCs–peripheral blood, DGC	50, 100, & 200 μg/ml	7 days	↘	↗
Scheubel et al. [40]	2006	Human EPCs–peripheral blood, DGC	2, 20, & 200 μg/ml	7 days	Low conc. ↗, high conc. ↘	↗
Shen et al. [41]	2010	Human EPCs–peripheral blood, DGC	2, 20, & 200 μg/l	24, 48, and 72 hours	↘	↗
Sun et al. [42]	2009	Human EPCs–peripheral blood, DGC	200 μg/ml	24 hours		↗
Zhu et al. [43]	2012	Human EPCs–peripheral blood, DGC	15 to 3704 μg/l or 250 to 1000 μg/l	24, 48, and 72 hours	↘	-

SC: stem cell; PC: progenitor cells; ↘: decrease; ↗: increase; -: no effect; EPCs: endothelial PC; PMBC: peripheral blood mononuclear cell; DGC: density-gradient centrifugation; MGO: methylglyoxal.