The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review

Table 2

Summary of included studies using EPCs isolated from the bone marrow. Summary of the isolation procedure and sampling, AGEs concentration, application duration, and effect on outcome measurement proliferation and apoptosis.

Study name	Year	Isolation PC	AGEs application		Effect on outcome
			Concentration	Duration	Proliferation	Apoptosis
Chen et al. [45]	2010	Rat–bone marrow, DGC	50, 100, 150, 200, & 400 μg/ml	24 hours	↘	↗
Chen et al. [46]	2016	Rat–bone marrow, DGC	400 μg/ml	24 hours	↘	↗
Jin et al. [47]	2018	Mice–bone marrow, DGC	100, 200, & 400 μg/ml	24 hours	↘	↗
Kim et al. [48]	2018	Mice–bone marrow, DGC	250, 500, 600, & 750 μM	24 hours	↘
Li et al. [49]	2017	Rat–bone marrow, DGC	200 μg/ml	24 hours		↗
Li et al. [50]	2012	Rat–bone marrow, DGC	50, 100, 200, & 500 μg/ml	24 hours		↗
Zeng et al. [51]	2017	Rat–bone marrow	200 μg/ml	48 hours	↘	↗
Wang et al. [52]	2019	Rat–bone marrow, DGC	100, 200, & 400 mg/l	12, 24, and 48 hours	Low conc. ↗, high conc. ↘

PC: progenitor cells; ↘: decrease; ↗: increase; DGC: density-gradient centrifugation.