Molecular Mechanism of Stem Cell Differentiation into Adipocytes and Adipocyte Differentiation of Malignant Tumor

Figure 1

Regulation pathways in preadipocytes commitment. BMP and Wnt families are mediators of MSCs commitment to produce preadipocytes. Exposure of growth-arrested preadipocytes to differentiation inducers (IGF1, glucocorticoid, and cAMP) triggers DNA replication, leading to adipocyte gene expression due to a transcription factor cascade. The dotted line indicates an uncertain molecular regulatory mechanism.