Stem Cells International / 2021 / Article / Tab 2

Review Article

Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing

Table 2

Summary of research on immobilized Exos in wound repair.

ExosomeScaffoldModelFunctionReference

hUC-MSC-derived ExosPluronic F127 hydrogelDiabetic full-thickness skin woundAccelerate wound closure and promote tissue regeneration[85]
pH-responsive ExosPolysaccharide-based dressingChronic diabetic woundEnhance the angiogenic ability and sustained release of Exos[86]
Mouse ADSC-derived ExosPluronic F127 hydrogel, oxidized hyaluronic acid, and ε-polylysineRat diabetic cutaneous injurySustained release of Exos; promote angiogenesis, reepithelialization, neovascularization, and cell proliferation[87]
ADSC-derived ExosAlginate hydrogelFull-thickness excisional woundEnhance wound closure, reepithelization, collagen deposition, and angiogenesis[88]
ADSC-derived ExosPorous cryogelsDiabetic and infectious woundAccelerate wound closure, promote collagen deposition, increase reepithelialization and neovascularization, and decrease oxidative stress[79]
hUC-MSC-derived ExosHydromatrixSkin wound healingInhibit myofibroblast formation and reduce scar formation[89]
hUC-MSC-derived ExosGenipin-crosslinked hydrogelRat cutaneous woundReduce inflammation, promote wound closure, accelerate epithelial regeneration, and increase collagen deposition[90]
Gingival MSC-derived ExosChitosan/silk-based hydrogelRat diabetic woundPromote reepithelialization, deposition and remodeling of collagen, angiogenesis, and skin wound healing[89]
BMSC-derived ExosElectrospun fibrous scaffoldsFull-thickness skin woundSynergistic immunomodulatory functions toward skin wound repair[58]
ADSC-derived ExosPluronic F127 hydrogel, oxidized hyaluronic acid, and ε-polylysineDiabetic full-thickness cutaneous woundSustained release of Exos; promote neovascularization, accelerate the formation of granulation tissue, and enhance reepithelialization and collagen remodeling[91]
Placental MSC-derived ExosAldehyde methylcellulose–chitosan-g-PEG hydrogelFull-thickness skin defectSynergistically promote angiogenesis and inhibit cell apoptosis; promote the function of hair follicles and glands[92]

Abbreviations: ADSC: adipose-derived MSC; BMSC: bone marrow-derived MSC; hUC-MSC: human umbilical cord-derived MSC; PEG: polyethylene glycol.

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