Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds

Figure 3

Different treatment options for tendon repair: (a) physiotherapy facilitates faster healing and collagen realignment, preventing joint stiffness, resulting in elevated tensile strength, and better gliding; (b) surgical intervention is usually used and has several disadvantages such as poor integration, mechanical mismatch, necrosis, donor site morbidity tissue rejection, and disease transmission; (c) stem cell therapy facilitates tendon tissue regeneration process; (d) growth factor therapy aims attract stem cells at injury site, support attachment, proliferation, differentiation, and accelerate tendon regeneration; (e) gene therapy aspires to synthesize natural proteins that overcome the problems of externally delivered growth factors; (f) regenerative medicines (tissue engineering) accelerate natural healing process and design bioscaffolds (natural, synthetic, and composite) for the rehabilitation of tendon tissue, to deliver growth factors, to stimulate cell proliferation and differentiation. Reproduced with permission from references [53–57].