Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds

Table 3

Recent cell-based approach for tendon regeneration.

Cell line	Study type	Tendon model	Results	Reference
Tenocytes	Rabbit Achilles tendon	In vivo	Increased ECM production and enhanced orientation of collagen fibers	[82]
ADSC	Rabbit Achilles tendon	In vitro/in vivo	Production of tendon fibers with better (60%) tensile strength	[128]
Dermal fibroblast	Human patella refractory tendinopathy	Clinical trial	Increased tendon thickness, reduction in pain and enhanced mechanical strength	[131]
BM-MSC	Equine tendon model	In vitro/in vivo	Improved histological parameters, increased orientation of collagen fibers and decrease in cellularity	[141]
Muscle-derived stem cells	Muscle muscularis fascia of dorsum	In vivo	Enhanced stiffness, tensile strength and improved cross linking of collagen fibers	[90]
Periosteal progenitor cells	Rabbit infraspinatus tendon model	In vivo	Increased content of col-I & COL-II and enhanced ECM production	[128]
Tendon stem cells	Rat patella tendon model	In vitro/in vivo	Increased collagen fiber thickness, ECM deposition and production of col-I, II and Tnmd	[93]

Abbreviations: ADSC: adipose-derived stem cells; BM-MSC: bone marrow-derived mesenchymal stem cells.