Pluripotency-State-Dependent Role of Dax1 in Embryonic Stem Cells Self-Renewal

<div>Expression of self-renewal-related genes after Dax1KO in different pluripotency states. (a) Heatmap of the apoptosis-related genes, pluripotency-associated genes, and lineage commitment genes after Dax1KO in 2i/LIF and LIF/serum. (b) qRT-PCR analysis of the indicated genes. Data are normalized to Gapdh and shown relative to WT ESCs (set at 1.0). 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583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> All <svg height="8.68572pt" id="M17" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g></svg> values were calculated using Student’s <span class="nowrap"><svg height="8.02022pt" id="M18" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z"></path></g></svg>-</span>test.</div>

Stem Cells International

fig6

Figure 6

Figure 6: Pluripotency-State-Dependent Role of Dax1 in Embryonic Stem Cells Self-Renewal 