Stem Cells International / 2021 / Article / Tab 2

Review Article

Characteristics and Developments in Mesenchymal Stem Cell Therapy for COVID-19: An Update

Table 2

The characteristics and categories of EVs.

CharacteristicExosomesMicrovesiclesApoptotic bodies

Apoptotic bodies50–150100–1000500–2000
OriginMultivesicular body exocytosisCell membrane budding and fissionPlasma membrane, endoplasmic reticulum
MorphologyCup/round shapedVarious shapesHeterogeneous
Sucrose gradient1.13–1.19 g/mL1.04–1.07 g/mL1.16–1.28 g/mL
Surface markersAnnexins, tetraspanins, heat-shock proteinsCD40, cholesterol, sphingomyelin, ceramideAnnexin V positivity, TSP, C3b
ContentsProteins, nucleic acids, lipidProteins, nucleic acids, lipidNuclear fractions, DNA, cell organelles
Isolation techniqueCentrifugation at 100,000 gravityUltracentrifugationUltracentrifugation

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