Hydrostatic Pressure Modulates Intervertebral Disc Cell Survival and Extracellular Matrix Homeostasis via Regulating Hippo-YAP/TAZ Pathway

<div>Effect of hydrostatic pressure on synthesis of collagen type II of the rabbit notochordal NP and fibrocartilaginous inner AF: (a) collagen type II IHC staining of the notochordal NP under graded hydrostatic pressure (200x); (b) statistic analysis of IHC collagen type II AOD value of the notochordal NP under graded hydrostatic pressure; (c) collagen type II IHC staining of the fibrocartilaginous inner AF under graded hydrostatic pressure (200x); (d) statistic analysis of IHC collagen type II AOD value of the fibrocartilaginous inner AF under graded hydrostatic pressure. <span class="nowrap"><svg height="10.7395pt" id="M19" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 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Stem Cells International

fig5

Figure 5

Figure 5: Hydrostatic Pressure Modulates Intervertebral Disc Cell Survival and Extracellular Matrix Homeostasis via Regulating Hippo-YAP/TAZ Pathway 