Treatment of Radiation Bone Injury with Transplanted hUCB-MSCs via Wnt/β-Catenin

Figure 5

hUCB-MSCs can save bone loss by improving the bone marrow microenvironment. (a) H&E of humerus sections from mice with control, MSC treatment, and irradiated. The black line showed the distance between the bone surface and the adjacent bone marrow tissue (scale bar, 100 μm). (b) Transmission electron microscopy images of humerus sections from mice with control, MSC treatment, and irradiated. The black arrowhead points to osteoprogenitor cells. The white arrowhead points to immature osteocytes and osteogenic phenomena (scale bar, 50 μm). (c) α-SMA staining of humerus sections from mice with control, MSC treatment, and irradiated (scale bar, 25 μm). (d) Immunohistochemistry of humerus sections from mice with control, MSC treatment, and irradiated (scale bar, 250 μm). (e) H&E of humerus sections from mice with control, MSC treatment, and irradiated. The black arrowhead points to fat cells (scale bar, 250 μm). (f) TRAP staining of humerus sections from mice with control, MSC treatment, and irradiated. The black arrowhead points to osteoclasts (scale bar, 25 μm). (g) Statistics of osteoid width in the control, MSC treatment, and irradiated groups. (h) Statistics of fat particles in the control, MSC treatment, and irradiated groups. (i) Statistics of osteoclasts in the control, MSC treatment, and irradiated groups. All data are ; .

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