Research Article

miR-375 Promotes Pancreatic Differentiation In Vitro by Affecting Different Target Genes at Different Stages

Figure 3

Overall description of differentially expressed genes (DEGs) in the four differentiation stages for control vs. miR-375 overexpression (OE) and control vs. miR-375 inhibition. (a) Heatmap showing the expression of DEGs in the miR-375OE group and the miR-375 inhibition group compared with the control group in different stages of differentiation. Hierarchical clustering was used to cluster gene expression patterns, and its expression level was standardized to TPM. (b) Venn diagram showing the distribution of DEGs in the four stages of differentiation in OE vs. control and bar plot showing the top 45 pathways of KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment, presented in descending order by gene number. (c) Venn diagram showing the distribution of DEGs in the four stages of differentiation for IE vs. control and bar plot showing the top 15 pathways of three GO (gene ontology) terms: BP (biological process), CC (cellular component), and MF (molecular function).
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