Lin28 Inhibits the Differentiation from Mouse Embryonic Stem Cells to Glial Lineage Cells through Upregulation of Yap1

Figure 6

Induction of Yap1 by Lin28a/b in mouse ESCs was independent of Let7 pathway. (a) Western blot analyses of total proteins from Lin28a OE mouse ESCs treated with different concentrations of Lin28-let7 inhibitor (LI71) using the indicated antibodies. (b) Western blot analyses of total proteins from Lin28a OE mouse ESCs treated with different concentrations of Lin28-let7a antagonist using the indicated antibodies. (c) Schematic of the Lin28a/b-Yap1 pathway activity regulating mouse ESC differentiation to glial lineage cells.

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