Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related Diseases

Figure 2

The supplementation of NMN may restore NAD level and SIRT1 activity. The circles filled with gray suggest involved enzymes, while the blue suggest related intermediates. The red arrows with a number on it illustrate the influence of NMN supplementation in order. NMN: nicotinamide mononucleotide; NR: nicotinamide riboside; ENT: equilibrative nucleoside transporters; CX43: connexin 43; NAMPT: nicotinamide phosphoribosyl transferase; NRK: nicotinamide riboside kinase 1; NMAT2: nicotinamide mononucleotide adenylyltransferase; NAM: nicotinamide.