Research Article

Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic Peripheral Neuropathy

Figure 4

Effect of MSC on the expression of the antioxidant factors, Sod and Nrf2, in the sciatic nerve and dorsal root ganglia of mice with OXL-induced chronic neuropathy. Two weeks after the OIPN model induction, mice were treated with MSC (OXL+MSC) or vehicle (OXL+saline) by endovenous route. Control group received 5% dextrose instead of OXL. The levels of mRNA in the sciatic nerve (a, b) and DRG (c, d) were measured by RT-qPCR 4 weeks after treatment. Target gene expression is represented normalized by the internal control gene, Gapdh. Data are expressed as ; mice per group. #Statistical significance relative to the OXL+vehicle group (), as determined by one-way ANOVA followed by Tukey’s multiple comparison test.
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