Stem Cells from Human Exfoliated Deciduous Teeth Attenuate Trigeminal Neuralgia in Rats

Figure 2

Effect of SHED transplantation on neuropathic pain. (a) Scheme showing the timing of SHED transplantation and behavioral testing. (b) The mechanical threshold was significantly decreased in CCI-ION rats. (c) Changes in the mechanical threshold after direct injection of low-dose ( cells, 0.2 mL, CCI-ION+low-dose injSHED group) or high-dose ( cells, 0.2 mL, CCI-ION+high-dose injSHED group) SHED into the site of injury were measured for 56 days in CCI-ION rats. Local injection of medium (CCI-ION+injMedium group) was used as a control. (d) Changes in the mechanical threshold after infusion of SHED ( cells, 0.2 mL, CCI-ION+infSHED group) through the tail vein were measured for 56 days in CCI-ION rats. Infusion of medium (CCI-ION+infMedium group) was used as a control. vs. sham (b), vs. medium (c, d), and ^# vs. day 0. All data are expressed as the ( rats in each group).

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