Review Article

Progress in Mesenchymal Stem Cell Therapy for Ischemic Stroke

Table 2

Gene transfection in the treatment of IS with MSCs.

Transfected geneTransfected vectorCell typeDoseTransplantation routeAdministration timeOutcome (compared with normal MSCs)Reference

BDNFAdenovirushBM-MSCsIntracerebral injection24 hours after MCAOFewer apoptotic cells; smaller infarcted volume; improvement of neurological function[45]
GDNFAdenovirushBM-MSCsIntravenous injection3 hours after MCAOSmaller infarcted volume; higher function recovery[48]
HGFHerpes sim-plex virus type-1BM-MSCsIntracerebral injection2 or 24 hours after MCAOFewer apoptotic cells; smaller infarcted volume; higher function recovery[208]
PIGFAdenovirushBM-MSCsIntravenous injection3 hours after MCAOMore angiogenesis; smaller infarcted volume; higher function recovery[60]
FGF1pCMV6-entry vectorAD-MSCsIntravenous injection0.5 hour after MCAOFewer apoptotic cells; smaller infarcted volume; higher function recovery[61]
Ang; VEGF; Ang+ VEGFAdenovirushBM-MSCsIntravenous injection6 hours after MCAOAng/Ang+ VEGF: more angiogenesis; smaller infarcted volume; higher function recovery. VEGF: infarct size increased; function deteriorated[56]
VEGFAdenovirusBM-MSCsIntracerebral injection24 hours after MCAOMore angiogenesis; smaller infarcted volume; higher function recovery[170]
Hif-1αLentivirusBM-MSCsIntracerebral injection24 hours after MCAOLower level of proinflammatory cytokines; higher level of neurotrophins; smaller infarcted volume; higher function recovery[169]
TSP4LentivirusBM-MSCsIntravenous injection3 hours after MCAOHigher levels of Ang-1 and vWF; more angiogenesis; higher function recovery[209]
IL-10Adeno-associated virushBM-MSCsIntravenous injection0 or 3 hours after MCAOLower level of proinflammatory cytokines and microglial activation; smaller infarcted volume; higher function recovery[162]
CCR2LentivirusBM-MSCsIntravenous injection24 hours after MCAOMore homing; less BBB leakage; higher function recovery[159]
CCL2NonehUC-MSCsIntravenous injection1 and 4 days after MCAOMore homing; more angiogenesis and neurogenesis; less neuroinflammation; smaller infarcted volume; higher function recovery[160]
Ngn1RetrovirushBM-MSCsIntra-arterial injection2 hours after MCAOMore homing; fewer apoptotic cells; less neuroinflammation; higher function recovery[161]
NogginAdenovirusBM-MSCsIntravenous injection6 hours after MCAOMore neurogenesis; smaller infarcted volume; higher function recovery[164]