Roles of Mesenchymal Stem Cell-Derived Exosomes in Cancer Development and Targeted Therapy

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Source</td><td class="align_center">Effect</td><td class="align_center">Mechanism</td><td class="align_center">Model</td><td class="align_center">Ref</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">p53<sup>−/−</sup> mBM-MSC</td><td class="align_center">Promotion of the growth and metastasis of gastric cancer</td><td class="align_center">Delivery of UBR2 to p53<sup>+/+</sup> mBM-MSC and MFC cells by modulating the Wnt/<i>β</i>-catenin pathway</td><td class="align_center"><i>In vitro</i></td><td class="align_center">[<a href="/journals/sci/2021/9962194/#B48" target="_blank">48</a>]</td></tr><tr><td class="align_left">BM-MSC</td><td class="align_center">Promotion of the growth of osteosarcoma (MG63) and GC (SGC7901) cells</td><td class="align_center">Activation of the Hedgehog signaling pathway</td><td class="align_center"><i>In vitro</i></td><td class="align_center">[<a href="/journals/sci/2021/9962194/#B49" target="_blank">49</a>]</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>MSC: mesenchymal stem cell; p53<sup>−/−</sup> mBM-MSC: p53 deficient mouse bone marrow MSC; p53<sup>+/+</sup> mBM-MSC: p53 wild-type mouse bone marrow MSC; MFC: murine foregastric carcinoma; BM-MSC: bone marrow MSC; GC: gastric cancer; hUC-MSC: human umbilical cord MSC.<br/></div></td></tr></table>

<div>Effects and mechanisms of MSC-EXs on GC.</div>

Stem Cells International

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Table 2

Table 2: Roles of Mesenchymal Stem Cell-Derived Exosomes in Cancer Development and Targeted Therapy 