Chidamide Suppresses the Growth of Cholangiocarcinoma by Inhibiting HDAC3 and Promoting FOXO1 Acetylation

Figure 1

Amplified HDAC3 in CCA tissues indicates a poor prognosis of CCA patients. (a) Expression of HDAC I (HDAC1, 2, 3, and 8), II (HDAC4, 5, 6, 7, 9, and 10), and IV (HDAC11) in normal () and CCA samples () in TCGA database, as well as the correlation between HDACs and the survival rate of patients with CCA. (b) Immunohistochemistry of HDAC3 protein in cancer tissues () and normal bile duct tissues (). (c) Western blotting of HDAC3 protein in cancer tissues () and normal bile duct tissues (). , compared to the normal bile duct tissues. Data were shown as the . An unpaired -test was employed for data comparison between two groups, while one-way ANOVA with Tukey’s post hoc test was used for multigroup data comparison.

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