Research Article

Wharton’s Jelly-Derived Mesenchymal Stem Cells with High Aurora Kinase A Expression Show Improved Proliferation, Migration, and Therapeutic Potential

Figure 4

WJ-MSCs with high expression of AURKA and DOCK2 were more effective in reducing apoptosis of mouse skeletal myoblast cells (C2C12). (a) Inhibition of apoptosis was evaluated by protein expression levels of cleaved caspase-3 and cleaved PARP in apoptosis-induced C2C12 cells after coculture with WJ-MSCs. Normalized protein level indicates the value converted based on that of the control group. (b) Representative fluorescence images showed antiapoptotic effect of WJ-MSCs in apoptosis-induced C2C12 (green, apoptotic cells; blue, viable cells). The chart quantified the apoptotic cell rate of each group. Data are shown as . One-way ANOVA with Tukey’s multiple comparisons test. , , and .
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